868359-05-1(free base)
WAY-213613 hydrochloride
CAS: 868359-05-1(free base)
Molecular Formula: C16H14BrClF2N2O4
868359-05-1(free base) - Names and Identifiers
| Name | WAY-213613 hydrochloride |
| Synonyms | WAY-213613 hydrochloride WAY-213613 (hydrochloride) WAY-213613 hydrochloride (868359-05-1 free base) |
| CAS | 868359-05-1(free base) |
868359-05-1(free base) - Physico-chemical Properties
| Molecular Formula | C16H14BrClF2N2O4 |
| Molar Mass | 451.65 |
| Solubility | DMSO |
| Storage Condition | -20℃ |
868359-05-1(free base) - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.214 ml | 11.071 ml | 22.141 ml |
| 5 mM | 0.443 ml | 2.214 ml | 4.428 ml |
| 10 mM | 0.221 ml | 1.107 ml | 2.214 ml |
| 5 mM | 0.044 ml | 0.221 ml | 0.443 ml |
Last Update：2024-01-02 23:10:35
868359-05-1(free base) - Cell Experiment
WAY-213613 hydrochloride is a potent, selective, non-substrate reuptake GLT-1/EAAT2 inhibitor with an IC50 of 85 nM for eaat2. WAY-213613 hydrochloride was 59-fold and 44-fold selective for EAAT1 and EAAT3 (IC50 5 and 3.8 μm, respectively). WAY-213613 hydrochloride is inactive at ionotropic and metabotropic glutamate receptors. It is a potential tool for elucidating the function of eaat2.
Last Update：2023-08-16 21:32:38
868359-05-1(free base) - Reference Information
| biological activity | WAY-213613 hydrozolide is a potent, selective, non-substrate reuptake GLT-1/EAAT2 inhibitor, the IC50 for EAAT2 was 85 nM. WAY-213613 hydrochloride was 59-fold and 44-fold selective for EAAT1 and EAAT3 (IC50 5 and 3.8 μm, respectively). WAY-213613 hydrochloride is inactive at ionotropic and metabotropic glutamate receptors. It is a potential tool for elucidating the function of eaat2. |
| Target | IC50: 85 nM (Human EAAT2), 3.8 μm (Human EAAT3), 5 μm (Human EAAT1) |
Last Update：2024-04-09 02:00:13
